Genetic analysis of Drosophila neurons: Shal, Shaw, and Shab encode most embryonic potassium currents

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Genetic analysis of Drosophila neurons: Shal, Shaw, and Shab encode most embryonic potassium currents.

In this study, we perform the first genetic analysis of K+ currents in Drosophila embryonic neurons revealing the identity of the currents present. Unlike muscles, where the presence of Shaker is obvious, Shaker currents are not detectable in these neurons. In contrast, we show that Shal is as important in these neuronal cell bodies as Shaker is in muscles. Only three single-channel currents we...

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Lobster shal: comparison with Drosophila shal and native potassium currents in identified neurons.

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The major delayed rectifier in both Drosophila neurons and muscle is encoded by Shab.

The delayed rectifier K+ current in Drosophila is similar to the classical delayed rectifier, originally described by Hodgkin and Huxley. Drosophila provides unique tools of mutant analysis to unambiguously determine the genetic identity of this native K+ current. We identified the Shab gene as the exclusive gene underlying delayed rectifier currents in both muscle and neurons. In muscles, a ge...

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KChIP1 and frequenin modify shal-evoked potassium currents in pyloric neurons in the lobster stomatogastric ganglion.

The transient potassium current (I(A)) plays an important role in shaping the firing properties of pyloric neurons in the stomatogastric ganglion (STG) of the spiny lobster, Panulirus interruptus. The shal gene encodes I(A) in pyloric neurons. However, when we over-expressed the lobster Shal protein by shal RNA injection into the pyloric dilator (PD) neuron, the increased I(A) had somewhat diff...

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Shal and shaker differential contribution to the K+ currents in the Drosophila mushroom body neurons.

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1995

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.15-03-01741.1995